for a experiment i want to methylate a sec. amine. anybody has any idea how or where to find this sort of info on the web (very interested in the answer to the latest question)
By bill tindall on Friday, January 26, 2001 - 10:04 am:
do you want a quantitative reaction, that is, to do a derivatization, or do you just want to make some? I don't think there is a simple quantitative reaction. If you just want to make some, methyl sulfate or methyl iodide will do it, but you will also make some of the quat. salt.
By Anonymous on Saturday, January 27, 2001 - 04:54 am:
well, we think we see a metabolite of a drug. Msn-analisys points towards this. we like to confirm by making the methyl-ester. i tried to heat with MeI but this did not work.
thsanks for your iterest.
By Anonymous on Saturday, January 27, 2001 - 09:10 am:
methyl ester of an amine with MeI? I must be missing something?
By Tom M. on Monday, January 29, 2001 - 05:00 pm:
You could try the Eschweilier-Clark reaction, a reductive amination:
your compound + formaldehyde + formic acid heated to 100C should proceed to greater than 90% yield
The formic acid will be oxidized to carbon dioxide and an immonium ion intermediate will be reduced. If all else fails find an organic chemist not a chromatographer :0)
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