By Anonymous on Friday, October 4, 2002 - 05:07 am:
I would like to know about the effect of injector , detector temperatures being high in analysis of the above mentioned isomer .
By Murty on Friday, October 4, 2002 - 05:12 am:
Moreover is there a better method to obtain good peak shape in HPLC analysis ( with Chiral AGP column) . Well , the compund/product is Sertraline Hydrochloride and the cis(-) isomer in this analysis elutes with broadening of peak shape . Can there be a better method to obtain beeter peak shape
By Anonymous on Monday, October 7, 2002 - 01:59 am:
Dear murthy,
Have you tried by varying modifiers and different chiral columns.
By Murty on Tuesday, October 8, 2002 - 03:03 am:
yeah i have tried different modifiers but with only with one single chiral column namely Chiral AGP which is indended for the analysis of Sertraline HCl ( for determination of chiral impurity )
Could you suggest better column than the above mentioned for obtaining better peak shape ( both for Sertraline HCl and Cis (-) isomer)
By Anonymous on Tuesday, October 8, 2002 - 07:08 am:
Have you tried using GC method , I feel this may help you.
By Murty on Thursday, October 10, 2002 - 04:25 am:
could you please suggest the most probable and suitable stationary phase (column) for analysis
By Murty on Saturday, October 19, 2002 - 04:05 am:
is there a column ( as in HPLC) separately for the analysis of chiral compounds in GC .Please brief me .
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