I am presently working on GC to estimate trifluoroacetic acid in a drug. I find TFA peak is not symmetrical in almost all columns. Has anybody experienced with TFA in GC?
By Anonymous on Tuesday, November 25, 2003 - 07:06 am:
The best column I've come across for acids is a Free Fatty Acid Phase (FFAP) available from Phenomenex(ZB-FFAP), although I think most suppliers will do an equivalent. I've never actually tried TFA on that column but think it would be your best bet.
By Anonymous on Wednesday, November 26, 2003 - 04:02 am:
Can you not derivatize it?
By Anonymous on Sunday, November 30, 2003 - 08:23 pm:
I need to estimate the residual TFA (in the level of less than 0.2%). With this low level can I still derivatize it? Can you elaborate more on it?
By Anonymous on Thursday, April 22, 2004 - 01:17 am:
the HP-5 COLUMN WILL BE A GOOD CHOICE.THE PEAK IS GOOD,ONLY TFA COME OUT VERY FAST!