Acid chlorides...GC or LC?

Chromatography Forum: GC Archives: Acid chlorides...GC or LC?
Top of pagePrevious messageNext messageBottom of pageLink to this message  By mmm on Monday, August 2, 2004 - 12:31 pm:

I wondered if anyone could expand on the idea of analyzing acid chlorides without derivitization.Two of the impurities we are looking at derivitize into the same tri-ester.We have also tried normal phase HPLC (the main component is an anhydride)but response factor is unpredictable.This is espicially true for the main component.As the purity gets higher from 98%-99% the main component practically disappears.I was using a silica column, but will try a CN column to avoid any possible reaction with the silica.
Any information on a GC or LC method would be helpful.


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