We are new to the field of LC-MS could someone advise me of a book/article dealing with the choice of buffers/solvent systems for electrospray and the logic behind the choice. We have considerable LC experience.
Thanks!

Whatever is volatile is good. Reversed-phase chromatography with formic acid, ammonium formate, acetic acid, ammonium acetate, ammonium bicarbonate, ammonia. Other options are possible too, but less common. According to my MS expert, even non-volatile buffers are possible, if you have the right interface, work at a low enough concentration and don't mind cleaning the interface...