By April on Sunday, June 10, 2001 - 10:56 pm:
Hi,
1. Does anyone know about any free software or program on the net that could help calculate the pKa of a given structure?
2. Do you think ammonium bicarbonate is a "volatile-enough" buffer used in MS analysis? Will the drug be sticking onto the MS if the buffer is not volatile enough?
Thank you!
By Uwe Neue on Monday, June 11, 2001 - 03:15 pm:
Ammonium bicarbonate is volatile - NH3 - H2O - CO2 - no problem. The drug is not going to stick to the MS system, only the buffer, if it is not volatile enough.
By Joe Rongen on Monday, June 11, 2001 - 07:25 pm:
For question 1 - try some (free) software at: http://www.acdlabs.com/
Joe
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