I'm wondering whether maleic acid can be analyzed by a LC/MS. Thanks in advance!

It can be determined easily by Ion Chromatography using conductivity detection mechanism .. go to www.metrohm.com for applications / columns / methods / equipment ... use a HNO3 eluent ... other organic acids will be separated too ..

It looks like it should work by APCI neg. I am not sure about the chromatography, but I would start with amine or CN.

I'm sure it can, you just need to find the right conditions. Depending upon how much you're looking for, it can also be quantified using either reversed phase or ion exclusion with (low) UV or RI detection.

Maleate can be detected by negative electrospray with a single quadrupole MS at a mass/charge of 115. The separation is easily accomplished using the AS11 or AS11HC column, a sodium hydroxide eluent and an ASRS-Ultra suppressor (external water for continuous regeneration). This system can also have a conductivity detector in-line with the MS for additional information.

Yes Maleic acid can be PERFORMED SIMPLY by Ion Chromatography (Inorganic HPLC) with the Hypersil Carbohydrate column H+, with eluent 0.5mol/L H2SO4, 10% acetone 0.5ml/min (no chemical suppression necessary), Metrohm Ion Chromatography system, e.g. Metrohm 761 IC system using a conductivity detector. Injection volume 20ul.
Maleic elutes 10mins.... other organic acids separated too. Or uou can could just purchase a conductivity detector e.g. the Metrohm 732 conductivity detector to convert your existing HPLC system to a Ion Chromatography System .... your choice ...

Again, more BS from Metrohm! The inquiry specifically requested information about LC/MS! Can't you read Mr. anonymous? They weren't asking for a sales pitch. It's insulting to see that some of the Metrohm staff are trying to degrade this site into an open forum for sales pitches, especially when they don't even address the question being asked. All of the major HPLC manufacturers are capable of supplying equipment for performing ion exclusion applications so there's no need to mention a specific vendor. Since the customer was not asking about how to perform ion exclusion applications, there's no need to volunteer information about the wonders of the Metrohm instrumentation. Please leave your sales BS out of this forum!

WE LOVE CHRIS POHL!!!

Thanks for the honest advice. Working in impoverished academia, the last thing we want is sales pitches about pricy (and by the sounds of it rubish) kit. What we want is simple practical advice, that is why we visit this site. That is what it is all about!

Cheers!

Wooppss my mistake. Sorry about that! But the excitement of posting my third post on the chromatography forum was too much... I make sure I read the question properly next time.

OK I assume that the forum is for users, but because they use commercial equipment form a range of different suppliers will you no doubt get a range of opinions. I was not rude. I just tell it as it is. That it could be done simply by a Metrohm IC, and gave an example of the application. Was that so bad? Did it hurt anybody?

I will not be intimidated. I let the users decide.

If the hard working, impoverished academia has purchased a space rocket to complete the local shopping. That is their choice. I give them an alternative. Please remember that the real academia do not even have the money for the rocket let alone the rocket fuel.

Again, I let the user decide not the supplier. Preferably not rude ones!

Not too sure if ALL the suppliers have a high performance conductivity detector in their range.
Do Agilent have one?, Varian? Waters (which is CE marked)? I am not sure and would be interested to know? ... Anyway I let the users decide.

It works.
Ed Farmer

Mr. Farmer,

I read with interest your latest posting. Your rocket analogy is interesting. I am certainly not trying to intimidate you but rather to encourage you to follow normal common sense practices appropriate for this forum. Apparently my previous posting was too oblique for you. Let me succinctly restate the issues:

1). Please read the question and answer the question being posed. While it is appropriate to add additional commentary on other aspects not part of the original question, your answer should still be formulated in the context of the original question. Although you indicate that you accidentally posted an answer unrelated to the question, the majority of your postings have this characteristic! Perhaps you should try a little harder.

2). This forum should not be used as a basis for a sales pitch. It is inappropriate to incorporate information such as: model numbers of instrumentation (unless this is somehow of critical relevance to the discussion), prices, commentary on the "inexpensive" nature of the equipment, etc. The intent of this forum is to freely and openly discussed chromatography questions. This forum is not intended to be used as a means of free advertising! I doubt the readers of this forum will hold Metrohm in a positive light if you continue this egregious practice.

Chris Pohl

I am the person generating the initial question. I am running some samples containing maleate by LC/MS. We need to confirm the unknowns. Definitely the commercial guys from Metrohm are wasting our time. Actually we've never considered getting anything from a less known company!

I wish the kind experts always give their scientific thoughts rather than ADs.

Many thanks to Chris Pohl & Ph.D. Slave.