By Anonymous on Wednesday, February 18, 2004 - 10:20 pm:
I want to know exact mathematical way for calculating matrix effect of a plasma for any particular drug analysis, using lc/ms/ms.
By MG on Thursday, February 19, 2004 - 06:33 am:
One way is described in J. Mass Spectrom., 2003, 38, 823-838.
In summary: spike the same amount of analyte into solvent and blank plasma extracts, and ratio the peak areas.
By Anonymous on Thursday, February 19, 2004 - 03:50 pm:
There was also an article in Anal Chem June last year. The technique is simple, as described by MG. Preferentially, you do not want to have any matrix effects, since the matrix may be variable from sample to sample.
By Anonymous on Saturday, June 5, 2004 - 02:16 am:
There was a reference in Claustius Analytical lab web. Please refer this for your calrifcation.
By Anonymous on Monday, June 7, 2004 - 08:02 am:
Dear Anonymous,
Can you please give me the website address of
Claustius analytical lab.
Thanks