By Pim on Monday, March 1, 2004 - 12:24 pm:
Developping an LC method, I observed that only DMSO as organic modifier lead to a sufficiently good method. I wonder if this solvent can well be used if I furhter want to couple LC to MS?
By MG on Monday, March 1, 2004 - 03:28 pm:
I don't know how DMSO behaves as far as getting good ionization. I've never used it in my mobile phase. But there's another issue that could present a problem. Some ion source designs use PEEK tubing as the transfer line between the ESI needle (at ~ 5kV) and a grounded union, for safety. I think PEEK is incompatible with DMSO. Replacing that particular length with stainless steel would short the power supply.
By Anonymous on Monday, March 1, 2004 - 03:48 pm:
DMSO is NOT volatile.
By Anonymous on Monday, March 1, 2004 - 04:21 pm:
DMSO bp (760) 189 degrees...
By Anonymous on Monday, March 1, 2004 - 05:01 pm:
DMSO bp : 210-235 °C/760 mm Hg (lit.) degrees...
By Anonymous on Tuesday, March 30, 2004 - 05:12 am: