I posted a similar message on the LC board, but had no response. Maybe someone here can help me!
Can a review article or book recommended. What hardware (valves, retention gap dimension, etc.) are required. Does the technique work equally well for typical normal (e.g. hexane) and reversed phase solvents (e.g. water/acetonitrile)?
In general, what are the pitfalls and how can they be avoided? Thanks.

This is not an instrument for beginners. Contact the vendors in your area. Expect all the problems of an LC, an MS, and the interface, plus very sophisticated software (Windows on steroids), all at the same time. And, of course, the chemistry.

Attend as many seminars and meetings as you can, and don't buy anything until you can figure out what it might do for you. Be prepared to spend at least $150,000, and to dedicate the next few years of your life to the beast.

If your applications are a match with the system, it will all be worth it, but obviously, every application has its own potential, possibly unique, problems.

We own 3 systems, are buying a fourth, and could use 6. Within a few years, nearly all of our work will be done on these machines.

Good luck, and enjoy the journey!

SRI Instruments makes a commercial LC-GC combo system for about $13,000. The GC autosampler is plumbed in line with the LC effluent. When the LC detector detects a peak it triggers the GC autoinjector which then injects a few microliters into the GC for separation on any column and any GC detector or combination of detectors. See SRI's webstie at www.srigc.com

The 'Anonymous' posting above was an error...obviously! I read it TWICE as LC-MS before I added my 2 cents, and still didn't see LC-GC until the instant I pressed 'Post Message'.
I immediately requested the administrator to delete the post....oh well.

My apologies. Interesting question.