I am presently looking into software to assist in choice, optimisation and robustness of HPLC methods. I was wondering if anyone could highlight any fundamental differences between the above two sofware packages??
Thanks

I'll comment from the DryLab end: the two are complementary.

DOE software generally is intended to find an *optimum* combination of conditions based on a fixed number of experimental runs. DryLab is intended to find an *adequate* set of conditions based on the minimum possible number of experimental runs.

I can expand on that a little bit and say that if you have an existing method and want to tweak it or measure the robustness, then DOE software is the way to go. On the other hand, if you don't have a method, DryLab will give you faster answers as to what's feasible and what isn't.

If you want a more detailed look at the way DryLab is used, download the evaluation version from our web site http://www.lcresources.com/dldown.htm and look in the Help file under "Concise Guide to Method Development Using DryLab".

Also, if you want to e-mail me with your address, I can give you a call and answer any questions (failing that, give *me* a call at (800) 379-5221

-- Tom Jupille

Sally,

I would like to talk to you about ChromSword Auto for HPLC automatic method development, HPLC separation prediction and optimization of isocratic, linear and step gradients, pH, temperature, etc. Please contact me at 703-689-4981.

Thank you for your time,
Matt Kramer
Hitachi Instruments, Inc.
703-689-4981

Sally,

if you want to take a look at the original version of the optimization of isocratic, linear and step gradients, pH, temperature, etc., and not just at the copy of it, look into the first software of this type: DryLab at www.lcresources.com. You will save a lot of time.

Burt