I have been trying to find information about measuring individual peak areas of overlapped peaks, where a small peak of 0.1 to 1% sits on the tail of a much larger peak. Both tail asymmetrically. On traditional integrators you may usually either skim the small peak entirely (underestimating), perpendicular-drop (usually overestimating, or apply another algorithm such as an exponential skim. Do any other users have information or refs which will explain the most up to date approach to tackling this common problem. I have started with J.P.Foley's ref. Journal of Chromatography, 384 (1987)301-313.

Peak height works best in this situation.

Check also the chain: Quantitation of Peaks in the 0.1-1% Range, last entrance on Dec. 28, 2000 (found it again by entering "peak hight" into the keyword search).