I am looking for a procedure to analyze this compound by HPLC. I believe the matrix is a sunscreen material. Can anyone give me direction on this??

I have seen an application for sunscreens on a Thermo Hypersil-Keystone phase which includes octyl methoxycinnamate. This method is as follows
Column: BetaBasic 18, 5µm, 150x4.6
Mobile Phase: 0.01M Hexadecyl trimethyl ammonium bromine in 25% MeOH/37.5% Water/37.5% THF
Flow: 1.0 mL/min
Temp: 40°C
Detector: UV @ 325 nm.
A chromatogram can be found on page 136 of their catalogue. Hope this is of some help.

I can't give you the full method, since it is proprietary, but you can use a C-18 column (4.6 x 150)with methanol. You can check the UV absorption of the compound for max absorption. We detect at 305nm. Also, if you know that the only thing in your mixture the absorbs at the wavelength, you can just do it by UV.

Good Luck

Thanks a lot. That's a big help

HPLC conditions for analysis sunscreens contain Octyl methoxycinnamate
mobile phase MeOH:0.1% Phosphoric acid (85:15), column C18, Detection 300-310nm
Flow rate 1.0ml/min, you can do it.

There is a reference for a method in: “Reversed-Phase HPLC Analysis of Sunscreen Compounds” Hamilton Co. Reno, Nevada , The Application Notebook – September 2003 page 68

According to FDA, this compound should be referred to as: Octinoxate

I am going to have a thesis proposal for my degree in Chemistry. What possible topics can you suggest for my study? Something that is interesting... Thanks!