By Anonymous on Friday, August 23, 2002 - 06:17 am:
Hello,
is anyone of you have experiences of measuring log P by HPLC ? I work in a pharmaceutical company and this parameter is very important.
Can you give me also references of publications ?
Thanks a lot
Best regards.
By Fabiano on Tuesday, October 1, 2002 - 04:20 am:
Method for measuring the logarithm of the octanol¯water partition coefficient by using short octadecyl¯poly(vinyl alcohol) high-performance liquid chromatography columns, Journal of Chromatography A, Volume 952, Issues 1-2, 5 April 2002, Pages 47-61 Stephen F. Donovan and Mark C. Pescatore
Universal model for the calculation of all organic solvent¯water partition coefficients, Journal of Chromatography A, Volume 827, Issue 2, 11 December 1998, Pages 345-358
Francisco Torrens, José Sánchez-Marín and Ignacio Nebot-Gil
Measurement of partition coefficients by reversed-phase ion-pair liquid chromatography, Journal of Chromatography A, Volume 625, Issue 2, 20 November 1992, Pages 169-175
Hanfa Zou, Yukui Zhang, Mingfang Hong and Peichang Lu
bye
By Anonymous on Monday, October 7, 2002 - 06:36 am:
Thank you for your response Fabiano
Cordialy
By Anonymous on Tuesday, October 8, 2002 - 07:42 am:
There is a software called SciLogP from scivision.com for predicting logP from molecular structure. I don't know how it works.
PETER
By Fabiano on Wednesday, October 9, 2002 - 04:49 am:
there is also the ACD/Labs software(for windows) ,it also simulate the elution order in RPLC,
I already try it but I don't trust in the results.
but who knows?people believe in the NMR prediction of the same software...
there is also the Unix versions ,I think that the most famous is the Sybil for Sylicon Graphics.