I experienced LC system contamination so severe that I had to replace every component in the system that had sample contact to get rid of it. I was never able to isolate the problem. Can anyone suggest a generally acceptable post run system wash procedure that will help me to eliminate this problem in the future? Also, is there a reference for this?

What was the sample and what were the conditions under which you ran it. Anything from SPE to completely changing your method may be needed, but we don't have enough information to give a reasoned response based on what you've written.

Based on what little information you've given us Anon, I would wager that your contamination was not from one simple incident. Rather, it was a problem which was building up over time. But until you give us more info, as juddc wrote, we can't help you much. Sample identification, HPLC conditions (mobile phase composition, sample matrix, column type, perhaps type of system and tubing used) would all be useful.

Contamination may often be due to precipitation problems.

A good and simple rule is to always perform an off-line test on the solubility of the sample in the mobile phase.

In particular, in Ion Chromatography a single injection of a sample containing metals, in an alkaline eluent for anion analysis may cause severe damage to the system.