Is there any chromatographic methods for separation of the different polymorphic forms of a product. If not, other than XRD any other technique is there for the quantification of the polymorphs?

I doubt that there is such chromatographic procedure available. All crystalls have the same forms once dissolved, regardless of polymorphism. We have used IR to identify small pharmaceuticals for such purpose.

Recently when i am searching one of the patents method given such a method by PR HPLC analysis.
That's the reason for my question.

Please read the replies to the last string about
HPLC of polymorphs posted by Anonymous
on Saturday, May 4, 2002 - 05:39 am.

A polymorph is a crystal structure, when the
molecules are in solution, what effect will the
crystal structure that they once had, have on
their behaviour in solution?

DSC, DVS, IR, X-ray crystalography, solid
phase nmr, melting point analysis, optical
microscopy, and many more techniques will
differentiate between the polymorphs because
they analyse the material in the solid form.

I hope this helps....

Bhaskar,

Any specifics on the patent? It's more than a little difficult to understand how this is possible via chromatography since polymorphs wouldn't be expected to persist in solution.