Why do retention times of isomers correlate with their boiling points?

Chromatography Forum: LC Archives: Why do retention times of isomers correlate with their boiling points?
Top of pagePrevious messageNext messageBottom of pageLink to this message  By alan hale on Thursday, November 14, 2002 - 02:48 pm:

Why do retention times of isomers correlate with their boiling points?


Top of pagePrevious messageNext messageBottom of pageLink to this message  By Anonymous on Thursday, November 14, 2002 - 10:09 pm:

Are isomers different than other compounds? I would expect compounds with higher boiling points to have stronger hydrogen bonding and therefore be more polar and less retained on reverse phase HPLC


Top of pagePrevious messageNext messageBottom of pageLink to this message  By H W Mueller on Friday, November 15, 2002 - 06:44 am:

In molecular terms a higher cohesion leads to a higher bp, one may surmise that molecules with a higher cohesion might also interact more strongly with a stationary phase. I wouldn´t bet on that though, generally, as intermolecular forces are highly complex.
Hydrogen bonding is not the only mechanism for intermolecular attraction.


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