By Joe on Friday, January 17, 2003 - 10:05 am:
I'm attempting to analyze the polysorbate 80 concentration in a pharmaceutical matrix (at 50 ppm polysorbate 80). I have decent chromatography, including sufficient sensitivity. The difficulty lies in recovering the polysorbate from the matrix. The matrix contains a relatively high concentration of suspended microcrystalline cellulose (MCC), sodium CMC and dextrose. I have tried: 1) centrifugation to remove the MCC, and the supernatant does not test positive for polysorbate 80; 2) a couple of liquid:liquid extractions without pelleting the MCC, to no avail.
Any ideas would be greatly appreciated. Thank you for your help.
By maris on Friday, January 17, 2003 - 11:41 am:
Hi, Joe!
Sunday or monday I'll be able to give you some references.Please, remind me.
By jerry thoman on Wednesday, June 11, 2003 - 11:47 am:
It's very important to me that I get in touch with Joe, who had a message posted on January 17, 2003, as soon as possible. I hope he'll see this and contact me at the e-mail address cited below. Thanks so much!
By Joe on Thursday, June 12, 2003 - 09:00 am:
Jerry,
Please email me at joseph.runkle@westpharma.com
Thanks.
Joe