Method Validation - Acceptability of Parameters (Ex: Linearity)

Chromatography Forum: LC Archives: Method Validation - Acceptability of Parameters (Ex: Linearity)
Top of pagePrevious messageNext messageBottom of pageLink to this message  By Paula Tavares on Friday, March 7, 2003 - 08:08 am:

Acceptability of linearity data is often judged by examining the correlation coefficient and y-intercept of the linear regression line for the response versus concentration plot.

I have found in some papers these type of criteria:

1. The y-intercept should be included in the confidence interval (p=95%) around zero.

2. The y-intercept should be less than a few percent of the response obtained for the analyte at the target level.

My question is what must I understanding by "few %", and witch is the relation between these two criteria.


Add a Message


This is a private posting area. A valid username and password combination is required to post messages to this discussion.
Username:  
Password: