By Anonymous on Sunday, April 20, 2003 - 12:22 am:
Is there any Free website (apart from USP.org)in which we can read the contents of USP ?
By Anonymous on Sunday, April 20, 2003 - 07:44 am:
As an alternative, you can buy the book. It is not expensive. We have more than one (including older versions) in our lab.
By Anonymous on Monday, April 21, 2003 - 02:45 am:
I am working on a formulation having three active ingradients. I want to set method for dissolution test for this multicomponent formula. My problem is one of the early eluting peak ampong three components (RT about 3 min)is failing for peak purity test in acid stage only. Peak purity is passing in Buffer pH 6.8 and Mobile phase containing buffer and acetonitrile adjusted to pH 6.8.
My dilutions are
1 tab ---> 900 ml with 0.1N HCl
aliquote ---> diluted with mobile phase.or
1 tab ---> 900 ml with Buffer pH 6.8
aliquote ---> diluted with mobile phase.
My question is
1) What may be the reason.
2) What is possible remedy.
By Anonymous on Monday, April 21, 2003 - 02:08 pm:
On the waters Alliance you can inject from multiple vials in the same run:
10µl from the aliquote
20µl mobile phase added by the Alliance
I don't know what instrument you are working with, maybe it s possible with yours.
But 3 min is not mutch, are you sure your method is specific for degradants? Maybe you can adjust your method?
Have you already injected 0.1N HCL?