I am looking in to the use of IAM chromatography for use in in vitro ADME studies as a predictor of oral absorbtion of drug substance. I would very much appreciate peoples thoughts and experiences with this technique.

It's about as useful as measuring log P with RP HPLC, or distribution between octanol/water, or dodecane/water or some similar method. You want the compound to be as soluble in the membrane as in aqueous solution. Software programs can estimate this, but they don't always account for internal bonding in the molecule. These methods will tell you nothing about metabolism, half life, distribution and other things which are important to find bioavailable compounds. Use their shorter columns and a fast method, and remember that this technique will only give you the answer to a small piece of the puzzle.

I am looking in to the use of a Pulsed Electrochemical Detector/ HPLC for the analysis of Azithromycin .I would appreciate any thoughts/experiences with this detector.

I agee with T. Nolan. I used IAM chromatography for several years at another company, and while it did prove quite useful in some regards, you can get comparable results with simple log P determinations using classical methods or RP-HPLC methods.