By Bhaskar reddy.R on Wednesday, June 4, 2003 - 08:04 pm:
Dear All,
Can anybody suggest on chiral chromatographic conditions for the following molecule.
(S,S)-2,8 Diaza bicyclononane
Can we separate them by RPLC?
Please advice.
Bhaskar Reddy
By Anonymous on Thursday, June 5, 2003 - 04:13 am:
Have you considered SFC ??
By bhaskar Reddy.R on Monday, June 9, 2003 - 03:20 am:
No, We didn't have the equipment with us.
Can't we separate them by RPLC or chiral HPLC?
Thank you
By CSychov on Tuesday, June 10, 2003 - 05:36 am:
I think you can use for example Chiralcel OD - it resolves about 85% of enantimers. In this way? the mob/ phase is ...mmm... hexane-isopropanol-triethylamine 80-20-0.2 or somethihg of this kind. The problem is - how to detect? Refractometer?
By B.Buglio on Tuesday, June 10, 2003 - 05:19 pm:
You cant separate the enantiomers w RP. Why not
contact the tech services of a chiral column
manufacturer (eg ASTEC,Daicel )and see if they
will run your sample on their columns.You'll end
up w a column and mobile phase suggestion