By Fahim Gouveia on Sunday, January 11, 2004 - 03:36 pm:
Hi all,
Can anybody tell me under what signal to noise ratio (S/N) quantitation is not reliable anymore? How can we relate the S/N to the precision (accuracy) of quantitation? What is the document or literature that gives specifications on this issue?
Thank you very much for your time and attention.
By Anonymous on Sunday, January 11, 2004 - 09:36 pm:
Generelly, limit of detection (LOD) is set to 3:1 S/N and limit of quatitation (LOQ) to 10:1 S/N.
You should also test the injection precision at LOQ by preparing a sample that gives the S/N 10:1 ratio. This is usually max RSD% 10 or 5.
By Fahim Gouveia on Monday, January 12, 2004 - 07:45 am:
Thanks for the reply. What is the source (eg.,document or literature) that specifies these values? What is the meaning of RSD% (I´m sorry, but never heard about it)?
By Anonymous on Monday, January 12, 2004 - 08:23 am:
What is the source (eg.,document or literature) that specifies these values?
Try checking the USP.
What is the meaning of RSD%
RSD=relative standard deviation
By syx_gf on Thursday, May 20, 2004 - 05:31 pm:
%RSD = Coefficient of variation (RSD x 100)
RSD = SD/mean
%RSD = 100 x SD/mean
By Chemist on Tuesday, June 1, 2004 - 04:17 am:
Fahim, are you sure you working with LC?
Never heard of %RSD?
How do you now precision of instrument injections, sample reproducibility, etc...???