By Anonymous on Friday, March 12, 2004 - 03:08 am:
Can anyone help me out how to check the solubility of a new drug by HPLC to determine no. of water molecules present in the drug.
By DR on Friday, March 12, 2004 - 05:38 am:
HPLC is probably not the most efficient means of determining how much water is there.
We generally do % water by Karl Fischer titration or by Loss On Drying.