Acetaminophen solubility

Chromatography Forum: LC Archives: Acetaminophen solubility
Top of pagePrevious messageNext messageBottom of pageLink to this message  By Lisa Stockwell on Saturday, April 24, 2004 - 01:52 pm:

Can anyone tell me why paracetamol (acetaminophen) is more soluble in propanone than it is in water?


Top of pagePrevious messageNext messageBottom of pageLink to this message  By Anonymous on Wednesday, April 28, 2004 - 08:48 pm:

I don't think it is polar enough to go well in only water (R.T.), considering the aromatic ring. It's supposed to be "much" more soluble in warm/hot water. But it may go into mostly water with some organic, i.e. acetone/methanol/ethanol, to help it go in.


Top of pagePrevious messageNext messageBottom of pageLink to this message  By mauro veneroni on Friday, May 21, 2004 - 02:51 am:

I need to administer some acetaminophen to a mammal, via drinking water.
Is there anyone who can suggest which "edible" solvent can I us?


Top of pagePrevious messageNext messageBottom of pageLink to this message  By Chris Pohl on Sunday, May 23, 2004 - 07:38 pm:

Why not use the "solvent system" used in liquid cough medicine with acetaminophen. I'm not sure of the exact composition but I think the "solvent sytem" is mainly water and ethanol (but you can check on the package for other solvent ingredients).


Top of pagePrevious messageNext messageBottom of pageLink to this message  By DR on Monday, May 24, 2004 - 05:32 am:

acetaminophen is so foul tasting that you'd be doing the animal a favor by just shoving the correct portion of a pill down its throat, then giving it a drink, or use a children's liquid formulation (easier to titrate by weight).


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