By rr on Tuesday, July 13, 2004 - 11:58 pm:
According to European Pharmacopoeia signal to noise ratio is calculated as 2H/h, where H=height of the signal and h=noise level.
I do not understand why a multiplication factor of 2 is used.
According to the mentioned calculation in EP, the ratio of height of peak to noise has to be 1.5, to meet the Limit of Detection criteria of S/N=3
By ps on Friday, July 16, 2004 - 10:30 pm:
I too have the same question and this probably need to ask Ph.eur authorities itself.
But, What I presume is that the noise considered is the half of the noise of 'p to p'