By April on Wednesday, August 18, 2004 - 01:26 am:
Other than the reference "Ceyhan T et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.J Pharm Biomed Anal. 2001 Jun;25(3-4):399-406. " , have anyone done any HPLC determination of atropine sulfate and scopolamine hydrobromide and manage to get good separation?
By Ann on Wednesday, August 18, 2004 - 02:16 pm:
Hi April
Couple of (rather old) references here that might be useful. NB I haven't tried these methods so cannot comment on the separation achieved.
Oshima T et al.Application of ion-pair high performance liquid chromatography for analysis of hyoscyamine and scopolamine in solanaceous crude drugs. Pharm Bull (Tokyo). 1989 Sep;37(9):2456-8.
Pennington LJ, Schmidt WF.Belladonna alkaloids and phenobarbital combination pharmaceuticals analysis I: High-performance liquid chromatographic determinations of hyoscyamine-atropine and scopolamine. J Pharm Sci. 1982 Aug;71(8):951-3.
Best wishes, Ann