By Anonymous on Saturday, November 20, 1999 - 05:21 pm:
Could you please suggest an assay method (HPLC/GC/other) for cetylpyridinium chloride in a cream matrix? Any comments will be appreciated.
By Anonymous on Monday, November 22, 1999 - 05:18 am:
High performance liquid chromatography determination of residue levels on hicken carcasses treated with cetylpyridinium
chloride
Author: Zhou, X.; Handie, A.; Salari, H.; Fifer, E. K.; Breen, P.J.; Compadre, C.M.
Source: J. Chromatogr. B. / Year: 1999 / Volume: 728 /Page: 273-
[Quantitation of cetylpyridinium chloride by HPLC]
Author: Kanbashi, T; Ueyama, T
Source: Ann Report Nara Prefectural Pharmaceutical Lab / Year: 1987 / Volume: 9 /Page: 109-112
Bioadhesive lozenge for the improved delivery of cetylpyridinium chloride
Author: Collins, A.E.; Deasy, P.B.
Source: J. Pharm. Sci. / Year: 1990 / Volume: 79(2) /Page: 116
Ion chromatography for the analysis of household consumer products
Author: Murawski, D.
Source: J. Chromatogr. / Year: 1991 / Volume: 546 /Page: 351
Optimization of high performance liquid chromatographic analysis with UV detection: light-scattering detection to establish
the coelution of UV- and non-UV absorbing constituents
Author: Elfakir, C.; Lafosse, M.; Dreux, M.
Source: J. Chromatogr. / Year: 1990 / Volume: 513 /Page: 354
By Maciej on Wednesday, January 5, 2000 - 09:24 pm:
It was almost 8 years ago I worked with quantitative assay of cetylpirydinum chloride in candys (used in common cold). I do not remember much details, but I remember (I hope it's correct) I got a decent calibration curve (4-point curve with correlation coefficient R about 0.94; AUC conc. measure, NOT peak height) when I used C8/C18 (??? sorry, don't remeber!) column and the mobile phase MeOH/ACN 1:1 but the peak shape was not a textbook-like, though. Anyway, the method worked quite well and it was also quite easy to prepare the mobile phase, unlike the ion-pairing would require.
I remember that during the method evaluation I tried to used MeOH/water/TEA compositions in order to block silanols, and it was also promising, however I did not finish that approach.
The entire project was just aside of my main ones.
The problem you might have is extraction form the cream matrix. What do you try, if I may ask?
Best greetings,
Maciej Turowski
KIT
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