By Ana Guillen on Friday, February 18, 2000 - 12:30 am:
I'm trying to have an optimized method for the determination of doxycycline in porcine tissues: liver, skin + fat, muscle and kidney.
My LOD is 50 µg/g and the problem is the blank.
I can't obtein blank tissues enough. I think that is an extraction problem.
If is there anybody that had worked in this, and he knows an extraction method, I'm be pleased to be helped.
By Anonymous on Friday, February 18, 2000 - 02:32 am:
Determination of residues of tetracycline antibiotics in animal tissues by HPLC
Mulders, EJ; Van de Lagemaat, D
J Pharm Biomed Anal,1989,7(12),1829-1835
By Uwe Neue on Friday, February 18, 2000 - 07:24 pm:
We've describe a good generic method for SPE in J. Chromatogr. A 828 (1998), 273-281. The generic technique has been applied to plasma, animal tissue and urine.
Uwe Neue
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