By Ian Laubscher on Monday, February 28, 2000 - 04:47 am:
Anyone who can recommend a review article or book on how to interface the two techniques? I am especially uncertain about the construction and operation of the retention gap between the two instruments. What hardware are required to do this? Does the technique work equally well for typical normal (e.g.hexane) and reversed phase solvents (e.g water/acetonitrile)? What are the pitfalls of this coupled technique?
By ????? on Monday, March 6, 2000 - 11:32 am:
I can honestly say I have never heard of anyone doing (or wanting to do) LC-GC. Why would anyone want to do this? I want to understand.
?????
By Anonymous on Monday, March 6, 2000 - 11:42 am:
The only info on this topic that I found when I went searching was at...
http://www.varianinc.com/csb/hplcnote/lc14.html
By David McCalley on Tuesday, March 7, 2000 - 04:54 am:
You need to look up the series of papers by Konrad Grob on this subject. Many of them are in the Journal of Chromatography. He has also published (Huethig) a comprehensive book with a title something like "On-line coupled HPLC-GC". A commercial instrument was marketed by the company Carlo Erba some time ago. I don't know who owns Carlo Erba these days, or whether the instrument is still available.
David McCalley
By Ian Laubscher on Tuesday, March 7, 2000 - 08:49 pm:
Thanks "Anonymous" for the info found - also to David McCalley. I owe you a coke!
Ian
By Hugh Goldsmith on Wednesday, March 8, 2000 - 01:50 pm:
SRI Instruments has a commercial LC-GC combination system. The GC autosampler is placed in line with the LC effluent. When the LC detector detects a peak, the GC autosampler is triggered, injecting a few microliters of the LC peak onto the GC for separation and detection using any of the available GC columns and detectors. A complete system is about $13,000.
See the SRI website at www.srigc.com
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