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Peak Fronting; Column Life; and Column Conditioning

Why won't the column work right all the time?

Keywords: fronting; silanol tailing; column temperature; column void; LC-MS/MS; column life; pH 9; ammonium carbonate; inline filter; column conditioning; LC-UV

LC-GC 23(6) 566-574 (2005)

Ryan D. Morrison and John W. Dolan