Selectivity in Reversed-Phase LC Separations, Part I: Solvent-Type Selectivity

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Selectivity in Reversed-Phase LC Separations, Part I: Solvent-Type Selectivity

Methanol and acetonitriel are the two most popular organic solvents to use in the mobile phase for reversed-phase liquid chromatography (LC) separations. Tetrahydrofuran is also used to a lesser extent. Why are these solvents the most popular ones? Are there lternative solvents that should be tried? This month's "LC Troubleshooting" examines these and someother aspects of solvent selection for LC.

Keywords:solvent selectivity, solvent triangle, alternate solvents, tetrahydrofuran, MTBE, THF, series

LCGC28(12) 1022-1027 (2010)

John W. Dolan