Detective Work, Part IV: Chemical Problems with the Column -- Chemical Attack

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Detective Work, Part IV: Chemical Problems with the Column -- Chemical Attack

The silica-based packing in reversed-phase columns is not inert. Here we consider what happens when the mobile-phase pH is too high or too low.

keywords: pH problems, column problems, peak fronting, column collapse, loss of bonded phase, silica dissolution, series

LCGC 34(2) 106-113 (2016)

John W. Dolan